Cart
sales@molnova.com
Umeclidinium bromide
CAS No. 869113-09-7
Umeclidinium bromide( GSK573719A | GSK-573719A | GSK 573719A )
Catalog No. M16310 CAS No. 869113-09-7
Umeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
|
| 5MG | 69 | In Stock |
|
| 10MG | 113 | In Stock |
|
| 25MG | 201 | In Stock |
|
| 50MG | 332 | In Stock |
|
| 100MG | 498 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameUmeclidinium bromide
-
NoteResearch use only, not for human use.
-
Brief DescriptionUmeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs.
-
DescriptionUmeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs; demonstrates picomolar potency (-log pA2=23.9 pM) in an acetylcholine-mediated Ca(2+) mobilization assay in CHO cells transfected M3 mAChRs; dose dependently blocks Ach-induced bronchoconstriction with long duration of action in mice model of pulmonary diseases.COPD Approved.
-
In Vitro——
-
In Vivo——
-
SynonymsGSK573719A | GSK-573719A | GSK 573719A
-
PathwayGPCR/G Protein
-
TargetmAChR
-
RecptorM1mAChR|M2mAChR|M3mAChR|M4mAChR|M5mAChR
-
Research AreaInflammation/Immunology
-
IndicationCOPD
Chemical Information
-
CAS Number869113-09-7
-
Formula Weight508.4897
-
Molecular FormulaC29H34BrNO2
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 34 mg/mL
-
SMILESOC(C1=CC=CC=C1)(C2=CC=CC=C2)C34CC[N+](CC4)(CCOCC5=CC=CC=C5)CC3.[Br-]
-
Chemical Name1-Azoniabicyclo[2.2.2]octane, 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-, bromide (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Salmon M, et al. J Pharmacol Exp Ther. 2013 May;345(2):260-70.
2. Tal-Singer R, et al. Eur J Pharmacol. 2013 Feb 15;701(1-3):40-8.
3. Decramer M, et al. Respir Physiol Neurobiol. 2013 Jan 15;185(2):393-9.
4. Decramer M, et al. Lancet Respir Med. 2014 Jun;2(6):472-86.
molnova catalog
related products
-
AZD 8683
A highly potent, long acting muscarinic receptor M3 antagonist with pIC50 of 9.8, inhibits M3 receptor in guinea pig trachea with pA2 of 9.4.
-
Biperiden
Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.
-
Fesoterodine
Fesoterodine (PF-00695838) is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties.
